Digital ulcers in systemic sclerosis
نویسندگان
چکیده
منابع مشابه
Registry Evaluation of Digital Ulcers in Systemic Sclerosis
Digital ulcers are a very frequent complication of systemic sclerosis affecting about half of the SSc patients, and about 75% of the affected patients have their first DU episode within 5 years from their first non-Raynaud symptom. The lack of adequate classification criteria as well as the lack of knowledge of the development of DU have contributed to the opening of specific registries to bett...
متن کاملOptimal management of digital ulcers in systemic sclerosis
Raynaud's phenomenon and digital ulcerations are two common clinical features seen in patients with systemic sclerosis. They are painful and lead to significant morbidity and altered hand function within this patient population. While currently there are no US Food and Drug Administration (FDA)-approved medications for the treatment of digital ulcerations in the United States, clinical trials h...
متن کاملBosentan for digital ulcers in patients with systemic sclerosis.
Recurrent digital ulcers are manifestations of vascular disease in patients with systemic sclerosis (SSc). We report six patients with severe digital ulcers who were treated with bosentan administered p.o., 62.5-125 mg daily. The mean duration from the diagnosis of SSc to the initiation of bosentan was 9.5 years, and the observation period after bosentan administration was from 7 months to 4.5 ...
متن کامل[Sildenafil in the treatment of digital ulcers in patients with systemic sclerosis].
In systemic sclerosis, the collagen deposition, vasculopathy, and Raynaud phenomenon produce abnormalities in microcirculation that lead to ischemia, distal ulceration (DU) and, occasionally, necrosis of one or more phalanges.1 We report 2 cases in which sildenafil was used as a treatment option. The first case was a 46-year-old woman with a history of diffuse cutaneous systemic sclerosis diagn...
متن کاملDigital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist.
OBJECTIVE Recurrent digital ulcers are a manifestation of vascular disease in patients with systemic sclerosis (SSc; scleroderma) and lead to pain, impaired function, and tissue loss. We investigated whether treatment with the endothelin receptor antagonist, bosentan, decreased the development of new digital ulcers in patients with SSc. METHODS This was a randomized, prospective, placebo-cont...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2016
ISSN: 1462-0324,1462-0332
DOI: 10.1093/rheumatology/kew047